David E. Graham

degraham@cm.utexas.edu
Biochemistry
Assistant Professor, Faculty
David E. Graham

Contact Information

Office
WEL 4.260B
Office Phone
471-4491
Fax
471-8696

Research Group

Graham Lab

Education

AB, Cornell University (1995);   MS, University of Illinois at Urbana-Champaign (1998);   PhD, University of Illinois at Urbana-Champaign (2000); Postdoctoral Research, Virginia Polytechnic Institute and State University (2000-2003)

Awards

NSF Postdoctoral Fellow (2003, 2002)

Biosynthetic pathways

My research explores how biosynthetic pathways have evolved during the evolution of modern organismal lineages. In particular, we are interested in pathways from Methanococcus jannaschii, a hyperthermophilic microorganism that grows at 85

Representative Publications

  • Drevland, R.D., A. Waheed, and D. E. Graham.  "Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii." J. Bacteriol. 189 (2007): 4391-4400.

  • Graham, D.E. and G. Kramer.  "Identification and characterization of archaeal and fungal tRNA methyltransferases." Meth. Enzymol. 425 (2007) (in press) 

  • Helgadóttir, S. G. Rosas-Sandoval, D. Söll and D.E. Graham.  "Biosynthesis of phosphoserine in the Methanococcales." J. Bacteriol. 189 (2007): 575-582.

  • Lindahl, P.A. and D. E. Graham.  "Acetyl-CoA synthetases and nickel-containing carbon monoxide dehydrogenases."  Nickel and Its Surprising Impact in Nature, vol. 2 of Metal Ions in Life Sciences.  A. Sigel, H. Sigel and R.K.O. Sigel, eds..  John Wiley & Sons, Ltd. Chichester, UK., 2007.

  • Waters, E. et al.  "The genome of Nanoarchaeum equitans: Insights into early archaeal evolution and derived parasitism." Proc. Natl. Acad. Sci. USA. 100 (2003): 12984-12988.